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- #FREESTYLE LIBRE FLASH GLUCOSE MONITORING SYSTEM INVASIVE SKIN#
- #FREESTYLE LIBRE FLASH GLUCOSE MONITORING SYSTEM INVASIVE PATCH#
- #FREESTYLE LIBRE FLASH GLUCOSE MONITORING SYSTEM INVASIVE TRIAL#
#FREESTYLE LIBRE FLASH GLUCOSE MONITORING SYSTEM INVASIVE PATCH#
The chemical analyses indicated that the adhesive patch itself might not have been the actual source of IBOA. IBOA is likely released from the glue used to join the top and bottom part of the sensor, and subsequently migrates into the other parts of the sensor. In the present study, we report the case of a child with allergic contact dermatitis caused by IBOA in FreeStyle ® Libre. Informed consent was obtained from the patient's parents for publication of this case report and the accompanying images. Positive patch test to isobornyl acrylate in the concentrations of 0.1% (No. 5) as the control material provoked no reaction in the patient. 4) and Vaseline, used for the test chamber, (No. She also reacted positively with (+ or ++) to IBOA with all concentrations in the 48-h (Figure 2), 72-h and 7-day periods. The affected patient reacted positively with (++) to the adhesive part of the sensor. The chamber of this patch test was a Torii chamber (Torii Medical Plaza, Tokyo, Japan). Patch testing was carried out with the adhesive part of the sensor, and with acetone solutions of IBOA material, applied on the upper arm. IBOA raw material was used for the patch test in three different concentrations, 0.1% (No. We referred her to the Department of Dermatology at our hospital to determine the potential causative allergen leading to allergic dermatitis.Īllergic contact dermatitis caused by wearing the FreeStyle ® Libre.Ī patch test was initially carried out using a piece of the adhesive part of the sensor of the FreeStyle ® Libre, and subsequently by using the potential contact allergen in the sensor, IBOA, on the basis of literature 2.
#FREESTYLE LIBRE FLASH GLUCOSE MONITORING SYSTEM INVASIVE SKIN#
She had no skin reaction at the summer camp and also never experienced any skin reactions from any medical devices, such as insulin pump or infusion sets.
#FREESTYLE LIBRE FLASH GLUCOSE MONITORING SYSTEM INVASIVE TRIAL#
She used the FreeStyle ® Libre on a trial basis at a diabetic summer camp for 4 days carried out 5 months earlier. The redness and eruptions shortly aggravated (Figure 1) finally, the patient visited the Department of Pediatrics, Nihon University Hospital, Tokyo, Japan. She wore the FreeStyle ® Libre on her left arm the next day, she noticed redness and eruptions just beneath the adhesive part of the film, whereas the central needle opening remained unaffected. She switched to a flash glucose monitoring system (the FreeStyle ® Libre) in 2018. Case ReportĪn 8-year-old girl with type 1 diabetes was under regular treatment with multiple daily injections of insulin she managed her blood glucose levels with a traditional capillary blood glucose meter. Several Caucasian cases were previously described in the dermatological literature 2, but this is the first case of a Japanese pediatric patient with type 1 diabetes showing allergic contact dermatitis caused by IBOA using the FreeStyle ® Libre. We found IBOA as a relevant and causative contact allergen in this case. Isobornyl acrylate (IBOA CAS no.) originates from the sensor itself and then migrates to the adhesive part of the sensor 2. However, we experienced a case wherein a pediatric patient using FreeStyle ® Libre developed severe allergic contact dermatitis, which was caused by the adhesive part of the sensor. It can replace the classical capillary blood glucose meters and help improve patients' attitudes towards glycemic management. Subcutaneous glucose concentrations are subsequently obtained by scanning the sensor with a reader. The sensor and catheter are applied for up to 14 days with an applicator. The FreeStyle ® Libre consists of a sensor, affixed on the upper arm with an adhesive film, which analyzes real-time interstitial glucose levels through a central catheter inserted in the subcutaneous tissue. This innovative medical device does not require daily repeated finger pricks, and provides continuous and dynamic interstitial glucose levels presenting as ambulatory glucose profiles 1. The FreeStyle ® Libre (Abbott Diabetes Care, Witney, UK), a flash glucose monitoring system, has recently been used for continuous subcutaneous analysis of glucose profiles in patients with diabetes.